- Home
- Search Results
- Page 1 of 1
Search for: All records
-
Total Resources3
- Resource Type
-
00030
- Availability
-
30
- Author / Contributor
- Filter by Author / Creator
-
-
Hsu, Ku-Lung (2)
-
Beiter, Rebecca M. (1)
-
Bullock, Timothy N. J. (1)
-
Dias Teixeira, Karina L. (1)
-
Fernández-Castañeda, Anthony (1)
-
Franks, Caroline E. (1)
-
Gaultier, Alban (1)
-
Gemta, Lelisa (1)
-
Georgiev, Georgi A. (1)
-
Gh., Mohammad Sharifian (1)
-
Harris, Joel M. (1)
-
Hayes, Nikolas (1)
-
Hsu, Ku‐Lung (1)
-
Kitt, Jay P. (1)
-
Laurie, Gordon W. (1)
-
Libby, Adam (1)
-
McCloud, Rebecca (1)
-
McKown, Robert L. (1)
-
Nanziri, Sarah C. (1)
-
Odrich, Marc G. (1)
-
- Filter by Editor
-
-
null (1)
-
& Spizer, S. M. (0)
-
& . Spizer, S. (0)
-
& Ahn, J. (0)
-
& Bateiha, S. (0)
-
& Bosch, N. (0)
-
& Brennan K. (0)
-
& Brennan, K. (0)
-
& Chen, B. (0)
-
& Chen, Bodong (0)
-
& Drown, S. (0)
-
& Ferretti, F. (0)
-
& Higgins, A. (0)
-
& J. Peters (0)
-
& Kali, Y. (0)
-
& Ruiz-Arias, P.M. (0)
-
& S. Spitzer (0)
-
& Spitzer, S. (0)
-
& Spitzer, S.M. (0)
-
(submitted - in Review for IEEE ICASSP-2024) (0)
-
-
Have feedback or suggestions for a way to improve these results?
!
Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher.
Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?
Some links on this page may take you to non-federal websites. Their policies may differ from this site.
-
Franks, Caroline E. ; Hsu, Ku‐Lung ( , Current Protocols in Chemical Biology)
-
Seki, Scott M. ; Posyniak, Kacper ; McCloud, Rebecca ; Rosen, Dorian A. ; Fernández-Castañeda, Anthony ; Beiter, Rebecca M. ; Serbulea, Vlad ; Nanziri, Sarah C. ; Hayes, Nikolas ; Spivey, Charles ; et al ( , Science Signaling)
Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation. To understand how these compounds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell–mediated autoimmunity that mimics multiple sclerosis (MS). TH17 cells are believed to orchestrate MS pathology, in part, through the production of two proinflammatory cytokines: interleukin-17 (IL-17) and GM-CSF. We found that both TEPP-46 and DASA-58 suppressed the development of IL-17–producing TH17 cells but increased the generation of those producing GM-CSF. This switch redirected disease pathology from the spinal cord to the brain. In addition, we found that activation of PKM2 interfered with TGF-β1 signaling, which is necessary for the development of TH17 and regulatory T cells. Collectively, our data clarify the therapeutic potential of PKM2 activators in MS-like disease and how these agents alter T cell function.